Droncit
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Introduction
1. Droncit Tablets 50mg
2. Droncit Spot-on 20mg Solution
Presentation
1. Droncit Tablets 50mg
A pale yellow scored tablet containing 50 mg praziquantel (Ph. Eur.).
2. Droncit Spot-on 20mg Solution
A clear, colourless to slightly reddish, non-aqueous solution containing 20 mg praziquantel Ph Eur per 0.5 ml tube, for spot-on (cutaneous) application for cats.
Uses
1. Droncit Tablets 50mg
For the treatment of adult tapeworms in dogs and cats.
The product is effective against both immature and mature forms of adult tapeworms in both dogs and cats.
The product is a highly effective treatment against all the common species of tapeworms infecting dogs and cats in the United Kingdom and Ireland including Echinococcus granulosus, Taenia multiceps, Taenia hydatigena, Taenia ovis, Taenia pisiformis, Taenia taeniaeformis and Dipylidium caninum. Droncit is also effective against Echinococcus multilocularis.(see note under further information).
2. Droncit Spot-on 20mg Solution
For the treatment of tapeworms of cats. Droncit Spot-On is effective against mature and immature forms of Dipylidium caninum and Taenia species. The product is also effective against Echinococcus multilocularis.
Dosage & administration
1. Droncit Tablets 50mg
The recommended dose rate is 5 mg/kg (1 tablet per 10 kg bodyweight).
Dogs: | Body weight | |
2.5–5.0 kg | ½ tablet | |
6.0–10.0 kg | 1 tablet | |
11.0–20.0 kg | 2 tablets | |
21.0–30.0 kg | 3 tablets | |
Over 30 kg | pro rata | |
Cats: | ||
Adult cats | ½ tablet |
The tablets are administered by opening the animal's mouth and pushing the tablet over the back of the tongue so that it cannot be rejected. Alternatively, a tablet can be wrapped in a piece of meat or butter and offered to the animal or crushed and mixed with the food.
A single dose is all that is required. However, for dogs in rural areas and for packs of hounds this dose should be repeated every six weeks to ensure that newly acquired tapeworms are destroyed before reaching maturity. Dosing must be associated with strict control of the dog's diet to ensure that uncooked offal is not eaten.
Use during pregnancy and lactation
The product may be administered to pregnant females. It is safe to the female herself, to the unborn foetus and to the newborn young.
2. Droncit Spot-on 20mg Solution
The minimum dose rate is 8 mg/kg which equates to 1 tube per 2.5 kg bodyweight.
Bodyweight (kg) | Number of tubes | Quantity of Praziquantel (mg) | mg/kg Bodyweight |
1-2.5 | 1 | 20 | 8-20 |
>2.5-5 | 2 | 40 | 8-16 |
>5 | 3 | 60 | maximum 12 |
Administration
Remove one tube from the package. Hold tube in an upright position, twist and pull off cap. Use reversed cap to twist and remove seal from tube. See figure 1.
 |
Figure 1: Opening a tube |
Part the hair on the cat’s neck at the base of the skull until the skin is visible. See figure 2.
 |
Figure 2: Administration |
Place the tip of the tube on the skin and squeeze firmly several times to empty the contents directly onto the skin. Application at the base of the skull will minimise the opportunity for the cat to lick the product.
To minimise the possibility of run-off after application of more than one pipette, it is advised that the applications should be performed slowly to allow absorption and that it may be advisable to allow the contents of the previous tube to be absorbed before applying another.
Tapeworm infection is certain to re-occur unless control of the intermediate hosts such as fleas, mice, etc, is undertaken.
Flea control
Flea infestations can be controlled by the regular use of effective flea control remedies.
Mice control
If cats roam and hunt, contact with, and consumption of, mice and subsequent re-infestation with Taenia taeniaeformis is impossible to prevent.
It is recommended to re-apply Droncit Spot-On when signs of tapeworm infection re-appear or at monthly intervals.
Use During Pregnancy and Lactation
There are no contra-indications against use during pregnancy and lactation.
Price comparison
Contra-indications, warnings, etc.
1. Droncit Tablets 50mg
Droncit should not be administered to unweaned puppies and kittens, as such animals are rarely infected with tapeworms.
Do not administer to dogs weighing less than 2.5 kg.
In the interests of good hygiene, persons administering the tablets directly to the animal, or by adding them to the animal's food, should wash their hands afterwards.
2. Droncit Spot-on 20mg Solution
For external use only.
Do not use on cats weighing less than 1 kg bodyweight.
Occasionally a transient local reaction such as scurf or mild exudation may be observed at the application site following treatment.
The product is bitter tasting and salivation may occasionally occur if the cat licks the application site immediately after treatment. This is not a sign of intoxication and disappears after a short time without treatment.
Overdosing can lead to slight skin reactions which disappear without treatment within a few days.
Care should be taken to avoid the contents of the tube coming into contact with the eyes or mouth of the recipient animal.
Do not allow recently treated animals to groom each other.
Operator safety
This product can be irritant to the skin and eyes.
Care should be taken to prevent contact of the solution with the skin or eyes.
If contact with the skin occurs, wash off any skin contamination with soap and water immediately.
If accidental contact occurs with the eyes, flush the affected eyes thoroughly with clean fresh water.
In the event of skin or eye contact, seek medical advice if irritation persists and show the Doctor this package.
Do not stroke or groom animals until area of application is dry (typically around 1 hour after application).
Wash hands thoroughly after use.
Do not eat, drink or smoke during application.
Environmental safety
Any unused product or waste material should be disposed of in accordance with national requirements.
Pharmaceutical precautions
1. Droncit Tablets 50mg
Do not store above 25°C.
Store in a dry place.
Any part-used tablets should be discarded.
Any unused product or waste material should be disposed of in accordance with national requirements.
2. Droncit Spot-on 20mg Solution
Store away from food, drink and animal feeding stuffs.
Do not use after expiry date.
Packaging quantities
1. Droncit Tablets 50mg
Cartons containing 2 x 10 tablet blisters.
2. Droncit Spot-on 20mg Solution
Blister pack, packed into a cardboard box with an instruction leaflet, containing 4 tubes each containing 20 mg praziquantel in 0.5 ml.
Further information
1. Droncit Tablets 50mg
Fleas serve as intermediate hosts for one common type of tapeworm–Dipylidium caninum. To avoid reinfection with this parasite, flea control of the animal and its housing should be carried out at the same time. Unless flea control is complete an infected flea population may survive: i.e. retreatment of the animal may be necessary.
As a precautionary measure to prevent the establishment of E .multilocularis in the UK and Ireland, it is recommended that all dogs and cats entering the country be treated with praziquantel.
The spectrum of action of praziquantel covers all the important species of cestodes in dogs and cats. It specifically includes all Taenia species occurring in dogs and cats, Multiceps multiceps, Joyeuxiela pasquali, Dipylidium caninum, Mesocestoides species and Echinococcus multilocularis. Praziquantel is effective against all stages of development of these parasites occurring in the intestines of dogs and cats.
Praziquantel is rapidly absorbed by the animal and metabolized by the liver. It is excreted, entirely as metabolites, in the urine and faeces. Praziquantel impairs the normal tegument function of the parasite, making it permeable to excessive glucose loss and thereby more easily attacked by proteolytic enzymes. Because of this, whole tapeworms including the scolex are very rarely passed in the faeces following administration of the drug. Disintegrated and partially digested fragments may occasionally be seen in the faeces.
2. Droncit Spot-on 20mg Solution
Praziquantel, the active ingredient of Droncit® Spot-on is a pyrazinoisoquinoline derivative used widely as an anthelmintic for both human and veterinary medicine.
Praziquantel is effective against all stages of development of intestinal tapeworms. The substance is very rapidly absorbed and distributed throughout the parasite. Both in vivo and in vitro studies have shown that praziquantel causes severe damage to the parasite integument, resulting in contraction and paralysis. There is an almost instantaneous tetanic contraction of the parasite musculature and a rapid vacuolisation of the syncytial tegument. This rapid contraction has been explained by changes in divalent cation fluxes, particularly calcium.
Praziquantel is absorbed very rapidly and almost completely in the stomach and small intestine. Studies of the behaviour following oral administration have been conduced in rats, dogs, monkeys, sheep and humans. Depending on species, maximum serum levels are reached within 0.3 to 2 hours. The chemical is evenly distributed to all organs. The elimination half-lives of 14C-praziquantel and its metabolites are between 2 and 3 hours in rats, dogs, monkeys and sheep.
Praziquantel is rapidly metabolised in the liver in both humans and animals with the 4-hydroxycyclohexyl derivative as the main metabolite. Praziquantel is completely eliminated from the body within 48 hours; irreversible binding to body constituents has not been observed. Elimination is in the form of metabolites with virtually no parent compound excreted. Between 40% and 71% of the substance is eliminated in the urine and 13%-30% in the faeces.
No incompatibility has been observed between this product at the recommended dose and a range of common veterinary treatments.
Disclaimer
This site has been created by www.MedicAnimal.com for information purposes only. MedicAnimal is a proud retailer of Droncit but is not affiliated with or related to the manufacturer of Droncit and the contents of this site are neither sponsored or endorsed by the manufacturer of Droncit.